Pricing Table Particle

Quickly drive clicks-and-mortar catalysts for change
  • Basic
  • Standard Compliant Channels
  • $50
  • Completely synergize resource taxing relationships via premier market
  • 1 GB of space
  • Support at $25/hour
  • Sign Up
  • Premium
  • Standard Compliant Channels
  • $100
  • Completely synergize resource taxing relationships via premier market
  • 10 GB of space
  • Support at $15/hour
  • Sign Up
  • Platinum
  • Standard Compliant Channels
  • $250
  • Completely synergize resource taxing relationships via premier market
  • 30 GB of space
  • Support at $5/hour
  • Sign Up
In the News:
USC Stem Cell researcher Senta Georgia wins CIRM Discovery Inception award ... Read More
The Katherine G. Johnson Computational Research Facility will formally be dedicated ... Read More
MARIAN ANDERSON will be included on the redesigned $5 bill ... Read more
Morgan Tuck announces she's entering WNBA draft ... Read More
Grand Rapids native Morgan Tuck selected third overall in WNBA Draft ... Read More
Black History Month Dedication: Congratulations to the honorable Rochelle Robinson on ... Read More
Olympic medalist and Atlanta native Kristi Castlin on that history-making sweep ... Read More
Ford Motor Company’s Felecia Pryor Appointed HR Director in China ... Read More

August 5, 2016

By Cristy Lytal

Senta GeorgiaSenta Georgia—principal investigator at Children’s Hospital Los Angeles (CHLA), and assistant professor of pediatrics, and stem cell biology and regenerative medicine at USC—has a creative idea for helping children with a genetic form of diabetes and malabsorptive diarrhea called enteric anendocrinosis. And through its Discovery Inception program, the California Institute for Regenerative Medicine (CIRM) has put forth $180,000 to turn her idea into meaningful progress towards new stem cell-based treatments.

“We asked scientists to pitch us their best new ideas, things they want to test but that are hard to get funding for,” said C. Randal Mills, president and CEO of CIRM, the California agency charged with dispensing $3 billion in voter-approved dollars to stem cell researchers throughout the state. “We know not all of these will pan out, but those that do succeed have the potential to advance our understanding of stem cells and hopefully lead to treatments in the future.”

Patients with enteric anendocrinosis are born lacking gastrointestinal cells that produce hormones. During childhood, they also lose insulin-producing pancreatic cells known as beta cells and become severely diabetic.

To better understand this disease, Georgia and her colleagues will focus their studies on a young CHLA patient who has enteric anendocrinosis due to a mutation in a gene called NEUROGENIN3 (NEUROG3).

“Similar to other patients with enteric anendocrinosis, this child developed diabetes at the age of four,” said Georgia. “This suggests that NEUROG3 is not required for an embryo to develop beta cells initially, but is required for beta cells to function and survive after birth. This contradicts previous studies of how NEUROG3 works in mouse models and underscores the importance of understanding the way genes affect disease in the human context.”

In order to study this patient’s beta cells in a minimally invasive way, the researchers will rely on sophisticated stem cell technology. Using the Chang Stem Cell Engineering Facility, the researchers will reprogram the patient’s skin cells into induced pluripotent stem cells (iPSCs). Georgia’s team will use these iPSCs to generate beta cells with the patient’s unique genetics, including the NEUROG3 mutation.

They will then apply genome editing to correct the NEUROG 3 mutation in hopes that it will improve the beta cells’ survival and function. If these edited beta cells continue to thrive when transplanted into a diabetic mouse, this will be the first step towards developing a cell replacement therapy for this patient.

According to Georgia, “we hope that this study can create a precedent for how to generate new insulin cells for patients with genetic forms of diabetes. We hope that CHLA/USC can become a leader in providing new cellular therapies for patients with genetic diabetes in the future.”

Senta Georgia is a member of the Theta Mu Omega chapter.

Research & Design Team

Project Manager & Research Team Manager

Soror Hansonia Caldwell Harriford
Far Western Region
Alpha Gamma Omega Chapter
Research Team Member, Archivist & Oral History Curator
Soror Linda Simmons-Henry
Mid-Atlantic Region
Sigma Tau Omega Chapter
Research Team Member, Project Historian & Librarian
Soror Chrystal Tibbs
Great Lakes Region
Tau Alpha Omega Chapter
Research Team Member & Video Designer
Soror Cheryl Pender
Mid-Atlantic Region
Sigma Tau Omega Chapter
Project Intern
Soror Brittney Christianna Yancy
Great Lakes Region
Tau Alpha Omega Chapter
Ivy Leaf® Operations
Soror Eva Smith
General Member
Deputy Director
Soror Nicole Barrett
General Member
Online Exhibit Web Developer
Judith Blakey
Page Design,
Los Angeles
Senior Client Solutions Manager
Wendy Austwick
Freeman XP